Blocking integrin inactivation as an anti-angiogenic therapy

  • Saharinen P
  • Ivaska J
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Abstract

During angiogenesis, endothelial cell migration is coordinated by integrin‐mediated contact with the extra‐cellular matrix (ECM), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal and plasma membrane reorganization. A recent paper by Vitorino et al ([2015][1]) defined a new MAP4K4–moesin–talin–β1‐integrin pathway that could be therapeutically exploited to suppress pathologic angiogenesis.\r
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[1]: #ref-12

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Authors

  • P. Saharinen

  • J. Ivaska

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