Blood pressure disturbances and endothelial dysfunction markers in children and adolescents with type 1 diabetes

  • Machnica L
  • Deja G
  • Polanska J
 et al. 
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Objective: Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. Methods: The study group comprised 52 children and adolescents aged 14.07±3.03 years, with T1DM duration 5.13±2.18 years. 20 healthy controls with similar age and sex distribution were included. Chosen serum biochemical markers of endothelial damage: intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), sE-selectin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) as well as ambulatory blood pressure monitoring (ABPM) were performed in all subjects. Results: Patients with T1DM displayed significantly higher concentrations of chosen markers of endothelial dysfunction compared to controls (sVCAM-1 (ng/ml): 951.56±330.68 vs. 710.35±162.12, TNF-α (pg/ml): 16.63±8.32 vs. 9.41±4.23, IL-6 (pg/ml): 3.38±1.31 vs. 2.45±0.81; p

Author-supplied keywords

  • ABPM
  • Blood pressure
  • Endothelial dysfunction
  • Type 1 diabetes

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  • L. Machnica

  • G. Deja

  • J. Polanska

  • P. Jarosz-Chobot

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