Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

  • Knill R
  • Lok P
  • Strupat J
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 14


    Citations of this article.


Using a multiple gas phase equilibration technique, we determined the solubility of isoflurane in arterial blood at 37 degrees C obtained from patients anaesthetized with isoflurane. Goodness of fit of individual sets of data to a predicted decline of isoflurane concentration in successive equilibrated gas phases and reproducibility of results indicate that the analytical technique was acceptably accurate. In blood samples taken from twenty-three patients undergoing minor surgical procedures, the blood/gas partition coefficient of isoflurane was 1.20 +/- 0.08 (mean +/- S.D.). Individual values were not detectably related to absolute tension of isoflurane, preoperative haemoglobin concentration nor patient age. In samples taken from twenty neurosurgical patients, the blood/gas partition coefficient was slightly less, 1.14 +/- 0.09 (p less than 0.05), a difference we attribute to the effect of previously infused mannitol. In vitro, blood solubility of isoflurane was decreased by haemodilution with normal saline, mannitol 20 per cent or plasma, was increased by hypothermia (30 degrees C) and was decreased by hyperthermia (40 degrees C). We conclude that the solubility of isoflurane in human blood is approximately half that of halothane.

Author-supplied keywords

  • anaesthetics
  • solubility: partition coefficients
  • volatile: isoflurane

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • R. L. Knill

  • P. Y K Lok

  • J. P. Strupat

  • A. M. Lam

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free