Body composition and components of energy expenditure in children with end-stage liver disease

  • Greer R
  • Lehnert M
  • Lewindon P
 et al. 
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Background: Better understanding of body composition and energy metabolism in pediatric liver disease may provide a scientific basis for improved medical therapy aimed at achieving optimal nutrition, slowing progression to end-stage liver disease (ESLD), and improving the outcome of liver transplantation. Methods: Twenty-one children less than 2 years of age with ESLD awaiting liver transplantation and 15 healthy, aged-matched controls had body compartment analysis using a four compartment model (body cell mass, fat mass, extracellular water, and extracellular solids). Subjects also had measurements of resting energy expenditure (REE) and respiratory quotient (RQ) by indirect calorimetry. Nine patients and 15 control subjects also had measurements of total energy expenditure (TEE) using doubly labelled water. Results: Mean weights and heights were similar in the two groups. Compared with control subjects, children with ESLD had higher relative mean body cell mass (33 ± 2% vs 29 ± 1% of body weight, P

Author-supplied keywords

  • Body Composition; Body Height; Body Water; Body W
  • Indirect; Case-Control Studies; Chronic Disease;
  • article; body composition; calorimetry; child; cl
  • lipid; water

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  • R Greer

  • M Lehnert

  • P Lewindon

  • G J Cleghorn

  • R W Shepherd

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