OBJECTIVE: The aim of the present study was to assess the joint contribution of hypertension and body mass index to coronary heart disease risk. DESIGN Prospective study on men aged 50-59 years free of coronary heart disease at entry recruited in three regions of France (n = 7359) and in Northern Ireland (n = 2399).
PARTICIPANTS: The recruitment frame was based on industry and various employment groups, on health screening centers and general practice.
MAIN OUTCOME: Incident cases of effort angina, unstable angina, myocardial infarction and coronary death were recorded over a 5-year follow-up.
RESULTS: Compared with the reference group [body mass index (BMI) 25 kg/m2], the relative risk of coronary event was higher in the second (25 < or =BMI 27.6) and third BMI tertiles: 1.27 (95% confidence interval 0.94-1.70) and 1.14 (0.84-1.56) after adjustment for confounders and covariates, including diabetes, hypertension and lipoprotein levels. Further analyses revealed a significant interaction between hypertension and BMI on coronary disease risk (P
CONCLUSION: These results indicate that hypertension and overweight jointly increase coronary heart disease risk.
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