Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women

  • Pugnale N
  • Giusti V
  • Suter M
 et al. 
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OBJECTIVE: To evaluate, during the first postoperative year in obese pre-menopausal women, the effects of laparoscopic gastric banding on calcium and vitamin D metabolism, the potential modifications of bone mineral content and bone mineral density, and the risk of development of secondary hyperparathyroidism. SUBJECTS: Thirty-one obese pre-menopausal women aged between 25 and 52 y with a mean body mass index (BMI) of 43.6 kg/m(2), scheduled for gastric banding were included. Patients with renal, hepatic, metabolic and bone disease were excluded. METHODS: Body composition and bone mineral density (BMD) were measured at baseline, 6 and 12 months after gastric banding using dual-energy X-ray absorptiometry. Serum calcium, phosphate, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, bilirubin, urea, creatinine, uric acid, proteins, parathormone, vitamin D(3), IGF-1, IGF-BP3 and telopeptide, as well as urinary telopeptide, were measured at baseline and 1, 3, 6, 9 and 12 months after surgery. RESULTS: After 1 y vitamin D3 remained stable and PTH decreased by 12%, but the difference was not significant. Serum telopeptide C increased significantly by 100% (P

Author-supplied keywords

  • Adult
  • Body Mass Index
  • Bone Density/*physiology
  • Bone Remodeling
  • Calcium/metabolism
  • Female
  • Follow-Up Studies
  • Gastric Bypass/*adverse effects
  • Gastroscopy/methods
  • Humans
  • Hyperparathyroidism, Secondary/*etiology/metabolis
  • Middle Aged
  • Obesity, Morbid/*metabolism/surgery
  • Premenopause/metabolism
  • Risk Factors
  • Vitamin D/metabolism

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  • N Pugnale

  • V Giusti

  • M Suter

  • E Zysset

  • E Heraief

  • R C Gaillard

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