Brain edema in neurooncology: radiological assessment and management

  • Wick W
  • Kuker W
  • Küker W
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Vasogenic brain edema is a common diagnostic and management problem in brain tumor patients. Molecular mechanisms play a role in the pathophysiology, including abnormalities of tumor endothelium, vascular endothelial growth factor and leukotriene synthase. Edema diagnosis is facilitated by the development of neuroradiological imaging techniques, with diffusion-weighted imaging (DW-MRI) differentiating tumor grades or abscesses and tumors, and diffusion tensor imaging representing an advanced technique to potentially differentiate malignant glioma from metastasis or facilitate preoperative planning. Edema is a prognostic factor for meningioma and metastases but not for glioma. Therapy includes, amongst others, tumor-directed measures such as debulking surgery, radio- and chemotherapy. However, local therapeutic approaches might also induce or exacerbate edema formation. Peritumoral edema can usually be managed with corticosteroids. However, patients on corticosteroids are at greater risk of metabolic changes, Pneumocystis carinii pneumonia, and thromboembolism. More recently, inhibitors of cyclooxygenase-2 as well as boswellic acids have been explored as antiedema agents in patients with brain tumors.

Author-supplied keywords

  • Brain Edema/diagnosis/*drug therapy/etiology/*radi
  • Brain Neoplasms/complications/diagnosis/*radiograp
  • Brain tumor
  • COX-2
  • DW-MRI
  • Humans
  • Magnetic Resonance Imaging
  • Patient Care Management/*methods
  • Pulmonary Embolism/chemically induced
  • Steroids
  • Steroids/adverse effects/*therapeutic use
  • VEGF
  • Vasogenic edema
  • Venous Thrombosis/chemically induced

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Authors

  • W. Wick

  • W Kuker

  • W. Küker

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free