Brain sodium, potassium, and osmolality: effects on anesthetic requirement

  • Tanifuji Y
  • Eger E
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We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Serum hyperosmolality achieved by administration of 12 and 25% dextrose increased cerebrospinal fluid osmolality without appreciably altering cerebrospinal fluid sodium or MAC. Infusion of 5% dextraose produced hypo-osmolality of blood and cerebrospinal fluid. Cerebrospinal fluid sodium was diluted and MAC was reduced by 24%.

Author-supplied keywords

  • *Anesthesia, Inhalation
  • Animal
  • Brain/*metabolism
  • Dogs
  • Dose-Response Relationship, Drug
  • Halothane/*administration & dosage
  • Hyperkalemia/metabolism
  • Hypernatremia/metabolism
  • Osmolar Concentration
  • Potassium/*analysis/cerebrospinal fluid
  • Sodium/*analysis/cerebrospinal fluid
  • Support, U.S. Gov't, P.H.S.

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  • PMID: 568400
  • PUI: 8385159
  • ISSN: 0003-2999
  • SGR: 0017821917
  • SCOPUS: 2-s2.0-0017821917


  • Y Tanifuji

  • E I d Eger

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