Brain vulnerability to chemotherapy toxicities

  • Ahles T
  • 73

    Readers

    Mendeley users who have this article in their library.
  • 59

    Citations

    Citations of this article.

Abstract

Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. By using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. An impressive body of research supports the hypothesis that a subgroup of patients is vulnerable to post-treatment cognitive changes, although not exclusively related to chemotherapy. Further, imaging and animal model studies provide accumulating evidence of putative mechanisms for chemotherapy-induced cognitive change. Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging.

Author-supplied keywords

  • brain vulnerability
  • cancer
  • chemotherapy
  • cognition
  • oncology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Tim A. Ahles

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free