Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

  • M. K
  • F. K
  • A.C. A
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF- were increased in the early stages of BD, compared to controls. While TNF- and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF- showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD. Copyright © 2009 CINP.

Author-supplied keywords

  • *biological marker/ec [Endogenous Compound]
  • *bipolar I disorder
  • *brain derived neurotrophic factor/ec [Endogenous
  • adult
  • antidepressant agent/dt [Drug Therapy]
  • article
  • bipolar disorder/dt [Drug Therapy]
  • controlled study
  • cytokine/ec [Endogenous Compound]
  • disease course
  • disease duration
  • female
  • human
  • inflammation
  • interleukin 10/ec [Endogenous Compound]
  • interleukin 6/ec [Endogenous Compound]
  • major clinical study
  • male
  • mania
  • mood stabilizer/dt [Drug Therapy]
  • neuroleptic agent/dt [Drug Therapy]
  • priority journal
  • protein blood level
  • tumor necrosis factor alpha/ec [Endogenous Compoun

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Kauer-Sant'Anna M.

  • Kapczinski F.

  • Andreazza A.C.

  • Bond D.J.

  • Lam R.W.

  • Young L.T.

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free