Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa.

  • Budgell E
  • Maskew M
  • Long L
 et al. 
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Abstract

In resource-limited settings, early mortality on antiretroviral therapy (ART) is approximately 10%; yet, it is unclear how much of that mortality occurs in care or after lost to follow-up. We assessed mortality rates and predictors of death among 12,222 nonpregnant ART-naive adults initiating first-line ART between April 2004 and May 2012 in South Africa, stratified by person-years in care and lost. We found 14.6% of patients died and being lost accounted for a minority of deaths across multiple definitions of loss (population attributable-risk percent ranged from 10.4% to 42.5%). Although mortality rates in patients lost were much higher than in care, most ART-related mortality occurred on treatment.

Author-supplied keywords

  • Adolescent
  • Adult
  • Ambulatory Care
  • Anti-HIV Agents
  • Anti-HIV Agents: therapeutic use
  • CD4 Lymphocyte Count
  • Female
  • HIV Infections
  • HIV Infections: drug therapy
  • HIV Infections: epidemiology
  • HIV Infections: mortality
  • Humans
  • Lost to Follow-Up
  • Male
  • Middle Aged
  • South Africa
  • Young Adult

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Authors

  • Eric P Budgell

  • Mhairi Maskew

  • Lawrence Long

  • Ian Sanne

  • Matthew P Fox

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