A brief total synthesis of fumaramidine

  • Lamblin M
  • Couture A
  • Deniau E
 et al. 
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Abstract

The first total synthesis of the alkaloid fumaramidine is reported. The synthetic tactics involve the sequential construction of the isoindolinone template by a Parham cyclization process followed by benzylic lactam deprotonation, interception with the suitable carboxaldehyde and ultimate E1cb elimination. Final N-lactam deprotection completes the synthesis of the Z configured title compound. © 2006 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Alkaloids
  • Ene lactams
  • Isoindolinones
  • Parham procedure

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Authors

  • Marc Lamblin

  • Axel Couture

  • Eric Deniau

  • Pierre Grandclaudon

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