A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses.

  • Hoelscher M
  • Singh N
  • Garg S
 et al. 
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Abstract

Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.

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Authors

  • Mary A Hoelscher

  • Neetu Singh

  • Sanjay Garg

  • Lakshmi Jayashankar

  • Vic Veguilla

  • Aseem Pandey

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