Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses. © 2008 by the Infectious Diseases Society of America. All rights reserved.
CITATION STYLE
Hoelscher, M. A., Singh, N., Garg, S., Jayashankar, L., Veguilla, V., Pandey, A., … Sambhara, S. (2008). A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses. Journal of Infectious Diseases, 197(8), 1185–1188. https://doi.org/10.1086/529522
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