Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

  • Yoneshiro T
  • Matsushita M
  • Nakae S
 et al. 
  • 34


    Mendeley users who have this article in their library.
  • 12


    Citations of this article.


Brown adipose tissue (BAT) contributes to whole-body energy expenditure (EE), especially cold-induced thermogenesis (CIT), in humans. Although it is known that EE and CIT vary seasonally, their relationship with BAT has not been investigated. In the present study, we examined the impact of BAT on seasonal variations of EE/CIT and thermal responses to cold exposure in a randomized crossover design. Forty-five healthy male volunteers participated, and their BAT was assessed by positron emission tomography and computed tomography. CIT, the difference of EE at 27ºC and after 2-h cold exposure at 19ºC, significantly increased in winter compared to summer, being greater in subjects with metabolically active BAT (High BAT, 185.6 kcal/d, 18.3 kcal/d, P

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Takeshi Yoneshiro

  • Mami Matsushita

  • Satoshi Nakae

  • Toshimitsu Kameya

  • Hiroki Sugie

  • Shigeho Tanaka

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free