Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

  • Yoneshiro T
  • Matsushita M
  • Nakae S
 et al. 
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Abstract

Brown adipose tissue (BAT) contributes to whole-body energy expenditure (EE), especially cold-induced thermogenesis (CIT), in humans. Although it is known that EE and CIT vary seasonally, their relationship with BAT has not been investigated. In the present study, we examined the impact of BAT on seasonal variations of EE/CIT and thermal responses to cold exposure in a randomized crossover design. Forty-five healthy male volunteers participated, and their BAT was assessed by positron emission tomography and computed tomography. CIT, the difference of EE at 27ºC and after 2-h cold exposure at 19ºC, significantly increased in winter compared to summer, being greater in subjects with metabolically active BAT (High BAT, 185.6 kcal/d, 18.3 kcal/d, P

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Authors

  • Takeshi Yoneshiro

  • Mami Matsushita

  • Satoshi Nakae

  • Toshimitsu Kameya

  • Hiroki Sugie

  • Shigeho Tanaka

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