Caffeine eliminates psychomotor vigilance deficits from sleep inertia

  • Van Dongen H
  • Price N
  • Mullington J
 et al. 
  • 101


    Mendeley users who have this article in their library.
  • 114


    Citations of this article.


STUDY OBJECTIVES: This study sought to establish the effects of caffeine on sleep inertia, which is the ubiquitous phenomenon of cognitive performance impairment, grogginess and tendency to return to sleep immediately after awakening. DESIGN: 28 normal adult volunteers were administered sustained low-dose caffeine or placebo (randomized double-blind) during the last 66 hours of an 88-hour period of extended wakefulness that included seven 2-hour naps during which polysomnographical recordings were made. Every 2 hours of wakefulness, and immediately after abrupt awakening from the naps, psychomotor vigilance performance was tested. SETTING: N/A. PARTICIPANTS: N/A. Interventions: N/A. MEASUREMENTS AND RESULTS: In the placebo condition, sleep inertia was manifested as significantly impaired psychomotor vigilance upon awakening from the naps. This impairment was absent in the caffeine condition. Caffeine had only modest effects on nap sleep. CONCLUSIONS: Caffeine was efficacious in overcoming sleep inertia. This suggests a reason for the popularity of caffeine-containing beverages after awakening. Caffeine's main mechanism of action on the central nervous system is antagonism of adenosine receptors. Thus, increased adenosine in the brain upon awakening may be the cause of sleep inertia.

Author-supplied keywords

  • Adenosine
  • Awakening
  • Caffeine
  • Function of sleep
  • Nap sleep
  • Sleep deprivation
  • Sleep inertia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • H. P.A. Van Dongen

  • N. J. Price

  • J. M. Mullington

  • M. P. Szuba

  • S. C. Kapoor

  • D. F. Dinges

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free