cAMP, an activator of protein kinase A, suppresses the expression of Sonic hedgehog

  • Noveen A
  • Jiang T
  • Chuong C
  • 0


    Mendeley users who have this article in their library.
  • 28


    Citations of this article.


In Drosophila, it has been shown that protein kinase A and hedgehog have antagonistic actions during the formation of imaginal disks. In vertebrate skin, sonic hedgehog is expressed specifically in the feather bud epithelia. Using an in vitro explant culture model we showed that dibutyryl cAMP, a protein kinase A (PKA) activator, suppresses the expression of Sonic hedgehog, (Shh) and continuous feather growth. The results suggest that Shh and PKA also have antagonistic action during vertebrate skin morphogenesis.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Alexander Noveen

  • Ting Xin Jiang

  • Cheng Ming Chuong

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free