Cancer gene therapy targeting angiogenesis: an updated review

  • Liu C
  • Shen Z
  • Kung H
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti-angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy.

Author-supplied keywords

  • Angiogenesis Inhibitors/therapeutic use
  • Clinical Trials as Topic
  • Genetic Therapy/*methods
  • Humans
  • Neoplasms/blood supply/therapy
  • Neovascularization, Pathologic/*drug therapy/*gene

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • C C Liu

  • Z Shen

  • H F Kung

  • M C Lin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free