Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.

  • De Gottardi A
  • Spahr L
  • Ravier-Dall'Antonia F
 et al. 
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Abstract

Cannabinoid receptors CB1 and CB2 are expressed in the liver, but their regulation in fatty hepatocytes is poorly documented. The aim of this study was to investigate the effects of selective CB1 or CB2 agonists on the expression of key regulators of lipid metabolism.

Author-supplied keywords

  • Apolipoproteins B
  • Apolipoproteins B: metabolism
  • Arachidonic Acids
  • Arachidonic Acids: toxicity
  • Biological Transport
  • Blotting, Western
  • Cannabinoids
  • Cannabinoids: toxicity
  • Carnitine O-Palmitoyltransferase
  • Carnitine O-Palmitoyltransferase: metabolism
  • Dose-Response Relationship, Drug
  • Fatty Acid Synthetase Complex, Type I
  • Fatty Acid Synthetase Complex, Type I: metabolism
  • Fatty Liver
  • Fatty Liver: chemically induced
  • Fatty Liver: genetics
  • Fatty Liver: metabolism
  • Fatty Liver: pathology
  • Gene Expression Regulation
  • Gene Expression Regulation: drug effects
  • Hep G2 Cells
  • Hepatocytes
  • Hepatocytes: drug effects
  • Hepatocytes: metabolism
  • Hepatocytes: pathology
  • Humans
  • Lipid Metabolism
  • Lipid Metabolism: drug effects
  • Lipid Metabolism: genetics
  • Oleic Acid
  • Oleic Acid: toxicity
  • Phosphatidylcholine-Sterol O-Acyltransferase
  • Phosphatidylcholine-Sterol O-Acyltransferase: meta
  • Receptor Cross-Talk
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB1: agonists
  • Receptor, Cannabinoid, CB1: metabolism
  • Receptor, Cannabinoid, CB2
  • Receptor, Cannabinoid, CB2: agonists
  • Receptor, Cannabinoid, CB2: metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sterol Regulatory Element Binding Protein 1
  • Sterol Regulatory Element Binding Protein 1: metab
  • Triglycerides
  • Triglycerides: metabolism
  • Up-Regulation

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Authors

  • Andrea De Gottardi

  • Laurent Spahr

  • Florence Ravier-Dall'Antonia

  • Antoine Hadengue

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