Purpose: To determine the maximal tolerated dose of capecitabine with oxaliplatin + radiotherapy in a phase I study of localized esophageal cancer. Patients and Methods: Oxaliplatin (85 mg/m2) administered on days 1, 15, and 29. Capecitabine administered twice daily 5 days weekly; dose levels (DL) were 1, 1000; 2, 1250; and 3, 1500 mg/m2 with 50.4 Gy radiation. Results: Dose-limiting toxicity was reached at DL 3. Carboxylesterase expression in day 2 tumor specimens and induction correlated with response (p ≤ 0.05). Conclusion: The maximal tolerated dose was 85 mg/m2 of oxaliplatin, 1,250 mg/m2/day of capecitabine, and 50.4 Gy of radiation. Copyright © Informa Healthcare USA, Inc.
CITATION STYLE
Javle, M. M., Yang, G., Nwogu, C. E., Wilding, G. E., O’Malley, L., Vinjamaram, S., … Pendyala, L. (2009). Capecitabine, oxaliplatin and radiotherapy: A phase IB neoadjuvant study for esophageal cancer with gene expression analysis. Cancer Investigation, 27(2), 193–200. https://doi.org/10.1080/07357900802172093
Mendeley helps you to discover research relevant for your work.