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Journal article

Capnellenes from the soft coral Dendronephthya rubeola

Grote D, Hänel F, Dahse H, Seifert K ...see all

Chemistry and Biodiversity, vol. 5, issue 9 (2008) pp. 1683-1693

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Abstract

Four new acetoxycapnellenes 1-4, the first epoxyprecapnellene 5, along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7, have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L-929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max-Interaction inhibitors are therapeutically interesting compounds in oncology.

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Authors

  • Daniela Grote

  • Frank Hänel

  • Hans Martin Dahse

  • Karlheinz Seifert

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