Cardiac remodeling and function following exercise and angiotensin II receptor antagonism.

  • Libonati J
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The purpose of this study was to test the impact of chronic exercise training combined with selective angiotensin II receptor (AT1) antagonism on systolic blood pressure (SBP) and the left-ventricular pressure-volume relationship in normotensive, non-infarcted rat hearts. Wistar rats (N=19) were randomly assigned to either a sedentary control group (N=8) or an exercise-trained group (N=11). Losartan was administered to individually caged rats via the drinking water (10mg/kg/d). Exercise training consisted of running on a motorized driven treadmill for 6weeks at 30m/min, 60min/day, 5 days/week. Tail cuff SBP was measured weekly. Left ventricular performance was assessed in an ex vivo Langendorff isovolumic mode. One week of losartan treatment significantly reduced SBP in both groups by 13% relative to baseline (P

Author-supplied keywords

  • diastole
  • heart
  • hypertrophy
  • losartan
  • systolic function
  • training

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Joseph R Libonati

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free