Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients?

  • Gonzalez A
  • Maradit K
  • Crowson C
 et al. 
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OBJECTIVE: To compare the frequency of traditional cardiovascular (CV) risk factors in rheumatoid arthritis (RA) compared to non-RA subjects, and examine their impact on the risk of developing selected CV events (myocardial infarction (MI), heart failure (HF) and CV death) in these two groups. METHODS: We examined a population-based incidence cohort of subjects with RA (defined according to the 1987 American College of Rheumatology criteria), and an age- and sex-matched non-RA cohort. All subjects were followed longitudinally through their complete community medical records, until death, migration, or 1 January 2001. Clinical CV risk factors and outcomes were defined using validated criteria. The chi2 test was used to compare the frequency of each CV risk factor at baseline. Person-years methods were used to estimate the rate of occurrence of each CV risk factor during follow-up. Cox models were used to examine the influence of CV risk factors on the development of CV outcomes. RESULTS: A total of 603 RA and 603 non-RA subjects (73% female; mean age 58 years) were followed for a mean of 15 and 17 years (total: 8842 and 10,101 person-years), respectively. At baseline, RA subjects were significantly more likely to be former or current smokers when compared to non-RA subjects (p

Author-supplied keywords

  • Aged
  • Arthritis
  • Arthritis,Rheumatoid
  • Body Mass Index
  • Cardiovascular Diseases
  • Case-Control Studies
  • Chi-Square Distribution
  • Diabetes Mellitus
  • Disease
  • Family
  • Female
  • Follow-Up Studies
  • Health
  • Heart
  • Heart Diseases
  • Heart Failure
  • Humans
  • Hypertension
  • Incidence
  • Infarction
  • Male
  • Medical Records
  • Middle Aged
  • Minnesota
  • Morbidity
  • Myocardial Infarction
  • NO
  • Patients
  • Proportional Hazards Models
  • RA
  • Research
  • Rheumatology
  • Risk
  • Risk Factors
  • Sex Factors
  • Smoking
  • adverse effects
  • cardiac
  • cardiovascular
  • cardiovascular risk factors
  • complications
  • criteria
  • epidemiology
  • history
  • methods
  • mortality
  • myocardial
  • rheumatoid arthritis

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  • PMID: 17517756


  • A Gonzalez

  • Kremers H Maradit

  • C S Crowson

  • K V Ballman

  • V L Roger

  • S J Jacobsen

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