Carotid Artery Blood Flow Decreases after Rapid Head Rotation in Piglets

  • Clevenger A
  • Kilbaugh T
  • Margulies S
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Abstract

Abstract Modification of cerebral perfusion pressure and cerebral blood flow (CBF) are crucial components of the therapies designed to reduce secondary damage after traumatic brain injury (TBI). Previously we documented a robust decrease in CBF after rapid sagittal head rotation in our well-validated animal model of diffuse TBI. Mechanisms responsible for this immediate (0.39). The average carotid blood velocity did not differ between sham and injured animals (p=0.91). These data suggest that a reduction in global CBF after rapid sagittal head rotation may be partially mediated by a reduction in carotid artery flow, via vasoconstriction.

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Authors

  • Amy C. Clevenger

  • Todd Kilbaugh

  • Susan S. Margulies

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