Cartilage tumours and bone development: molecular pathology and possible therapeutic targets

  • Bovee J
  • Hogendoorn P
  • Wunder J
 et al. 
  • 6


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


As a group, cartilage tumours are the most common primary bone lesions. They range from benign lesions, such as enchondromas and osteochondromas, to malignant chondrosarcoma. The benign lesions result from the deregulation of the hedgehog signalling pathway, which is involved in normal bone development. These lesions can be the precursors of malignant chondrosarcomas, which are notoriously resistant to conventional chemotherapy and radiotherapy. Cytogenetic studies and mouse models are beginning to identify genes and signalling pathways that have roles in tumour progression, such as hedgehog, p53, insulin-like growth factor, cyclin-dependent kinase 4, hypoxia-inducible factor, matrix metalloproteinases, SRC and AKT, suggesting potential new therapeutic approaches.

Author-supplied keywords

  • *Bone Development
  • Animals
  • Antineoplastic Agents/therapeutic use
  • Bone Neoplasms/*genetics/pathology
  • Cartilage/metabolism/*pathology
  • Chondrosarcoma/*genetics/pathology
  • Gene Expression Regulation/*drug effects
  • Humans
  • Mice
  • Osteochondroma/*genetics/pathology
  • Pathology, Molecular

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • J V Bovee

  • P C Hogendoorn

  • J S Wunder

  • B A Alman

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free