Cathestatins, new cysteine protease inhibitors produced by penicillium citrinum

  • Woo J
  • Ono H
  • Tsuji T
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Abstract

New cysteine protease inhibitors, named cathestatin A and B, have been discovered as metabolites of Penicillium citrinum. Cathestatins were found to be decarbamidoyl analogs of estatins and showed a specific inhibition for cysteine proteases. Cathestatins suppressed parathyroid hormone (PTH)-stimulated 45Ca release in organ cultures of chick embryonic calvaria.

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Authors

  • Je Tae Woo

  • Hideki Ono

  • Tomoko Tsuji

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