What causes cell death in Parkinson's disease?

  • Gupta A
  • Dawson V
  • Dawson T
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease (PD). Several advances in the genetics of PD have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of PD, as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of PD based on understanding the molecular mechanisms of how mutations in genes linked to PD cause neurodegeneration.

Author-supplied keywords

  • Animals
  • Cell Death
  • Humans
  • Mutation
  • Neuroprotective Agents
  • Parkinson Disease
  • Protein-Serine-Threonine Kinases
  • alpha-Synuclein

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • A Gupta

  • V Dawson

  • T Dawson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free