What causes cell death in Parkinson's disease?

  • Gupta A
  • Dawson V
  • Dawson T
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Abstract

Currently, there is no proven neuroprotective or neurorestorative therapy for Parkinson's disease {(PD).} Several advances in the genetics of {PD} have created an opportunity to develop mechanistic-based therapies that hold particular promise for identifying agents that slow and even halt the progression of {PD,} as well as restore function. Here we review many of the advances in the last decade regarding the identification of new targets for the treatment of {PD} based on understanding the molecular mechanisms of how mutations in genes linked to {PD} cause neurodegeneration.

Author-supplied keywords

  • Animals Cell Death/*genetics/physiology Humans Mut

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Authors

  • A Gupta

  • V L Dawson

  • T M Dawson

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