CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?

  • Tettamanti S
  • Biondi A
  • Biagi E
 et al. 
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Abstract

Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we discuss how this genetically modified cell-based strategy could be relevant to the field of AML therapeutics.

Author-supplied keywords

  • AML
  • Anti-CD123
  • CAR-T cells
  • Immunotherapy
  • Leukemic stem cells

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