A CD44−/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer

  • Ahmed M
  • Aleskandarany M
  • Rakha E
 et al. 
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Abstract

A CD44−/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer. Breast cancer cells with high CD44 and low or absent CD24 (i.e. CD44+CD24−/low phenotype) are reported to have stem cell features. However, the clinical impact of CD24 and CD44 expression in tumours remains unclear. To explore the immunohistochemical expression of CD44 and CD24 (individually and combined) and their clinical value as prognostic and predictive markers. Immunohistochemical expression of CD24 and CD44 was studied in a large series of early primary invasive breast cancer tumours (n = 1036) prepared as a tissue microarray. Associations between the expression of each marker individually and in combination and clinico-pathological, molecular variables and patients' outcome were investigated. CD24 cytoplasmic expression was significantly associated with poor prognostic variables including high tumour grade, ER−, PR−, HER2+, p53+ and triple negative (TN) phenotype; P 

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Authors

  • Mohamed A H Ahmed

  • Mohammed A Aleskandarany

  • Emad A Rakha

  • Radwa Z A Moustafa

  • Ahmed Benhasouna

  • Christopher Nolan

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