Cell differentiation under the influence of rh-BMP-2

  • Wilke A
  • Traub F
  • Kienapfel H
 et al. 
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Bioactive bone growth factors will likely play an important role in the regeneration of bone. BMP-2 is known to promote osteoblastic cell differentiation and osteogenesis. Whether the BMPs act on human osteoblastic cells by increasing immature cell growth and/or differentiation is unknown. The goal of this study was to analyse possible effects of rhBMP-2 on cell differentiation using a human bone marrow cell culture. rhBMP-2 was added to the culture medium once. Fourteen days after addition of rhBMP-2 the cells were incubated with monoclonal antibodies. The cells were counted and analysed in a fluorescence-activating cell sorter (FACS). Compared to the controls there was an increasing effect on granulocytes, B cells and stem cells. The T-cells and monocytes show no increase or decrease after rhBMP-2 treatment. © 2001 Academic Press.

Author-supplied keywords

  • BMP-2
  • Cell culture
  • Cell differentiation

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  • A. Wilke

  • F. Traub

  • H. Kienapfel

  • P. Griss

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