Cell fusion contributes to pericyte formation after stroke

  • Piquer-Gil M
  • García-Verdugo J
  • Zipancic I
 et al. 
  • 24


    Mendeley users who have this article in their library.
  • 27


    Citations of this article.


Recent reports have shown that bone marrow-derived cells (BMDCs) contribute to the formation of vasculature after stroke. However, the mechanism by which mural cells are formed from BMDC remains elusive. Here, we provide direct evidence that the cell fusion process contributes to the formation of pericytes after stroke. We generated mouse bone marrow chimeras using a cre/lox system that allows the detection of fusion events by X-gal staining. In these mice, we detected X-gal-positive cells that expressed vimentin and desmin, specific markers of mature murine pericytes. Electron microscopy confirmed that fused cells possessed basal lamina and characteristics of pericytes. Furthermore, induction of stroke increased significantly the presence of fused cells in the ischemic area. These cells expressed markers of developing pericytes such as NG2. We conclude that cell fusion participates actively in the generation of vascular tissue through pericyte formation under normal as well as pathologic conditions.

Author-supplied keywords

  • Bone marrow transplant
  • Cell fusion
  • Mural cells
  • Pericytes
  • Stroke
  • Transdifferentiation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Marina Piquer-Gil

  • José M. García-Verdugo

  • Ivan Zipancic

  • María J. Sánchez

  • Manuel Álvarez-Dolado

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free