Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment

  • Chen J
  • Irianto J
  • Inamdar S
 et al. 
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This study adopts a combined computational and experimental approach to determine the mechanical, structural, and metabolic properties of isolated chondrocytes cultured within three-dimensional hydrogels. A series of linear elastic and hyperelastic finite-element models demonstrated that chondrocytes cultured for 24 h in gels for which the relaxation modulus is

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  • J. Chen

  • J. Irianto

  • S. Inamdar

  • P. Pravincumar

  • D. A. Lee

  • D. L. Bader

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