Cellular Responses to DNA Damage: One Signal, Multiple Choices

  • Su T
  • 189

    Readers

    Mendeley users who have this article in their library.
  • 146

    Citations

    Citations of this article.

Abstract

DNA double-strand breaks (DSBs) produce a number of cellular re-sponses, some mutually exclusive. Depending on where on the chro-mosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What deter-mines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Tin Tin Su

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free