DNA double-strand breaks (DSBs) produce a number of cellular re-sponses, some mutually exclusive. Depending on where on the chro-mosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What deter-mines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.
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