Central nervous system vasculitis in children

  • S.M. B
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Abstract

Central nervous system (CNS) vasculitis is an increasingly recognized, often devastating inflammatory brain disease of children and adults. In primary or isolated CNS vasculitis/angiitis of childhood (cPACNS), the vascular inflammation is limited to the brain and spinal cord. Secondary CNS vasculitis occurs in a variety of conditions including infections, collagen vascular diseases, systemic vasculidities, and malignancies. Mimics of CNS vasculitis in children include dissections and noninflammatory vasculopathies. Diagnosis of primary CNS vasculitis in both adults and children is based on the Calabrese criteria. This review summarizes recent data on CNS vasculitis in children; reviews the clinical spectrum at presentation and the role of laboratory tests, neuroimaging, and brain biopsy; and discusses treatment strategies, outcome data, and overlapping conditions of cPACNS. Copyright 2006 by Current Science Inc.

Author-supplied keywords

  • *brain vasculitis/di [Diagnosis]
  • *brain vasculitis/dt [Drug Therapy]
  • *brain vasculitis/ep [Epidemiology]
  • *brain vasculitis/et [Etiology]
  • Varicella zoster virus
  • acetylsalicylic acid/dt [Drug Therapy]
  • aciclovir/ad [Drug Administration]
  • aciclovir/cb [Drug Combination]
  • aciclovir/dt [Drug Therapy]
  • aciclovir/po [Oral Drug Administration]
  • azathioprine/ad [Drug Administration]
  • azathioprine/cb [Drug Combination]
  • azathioprine/dt [Drug Therapy]
  • azathioprine/po [Oral Drug Administration]
  • brain angiography
  • brain biopsy
  • cerebral artery disease/dt [Drug Therapy]
  • cerebrospinal fluid analysis
  • clinical feature
  • clinical trial
  • computer assisted tomography
  • corticosteroid/cb [Drug Combination]
  • corticosteroid/ct [Clinical Trial]
  • corticosteroid/dt [Drug Therapy]
  • corticosteroid/iv [Intravenous Drug Administration
  • corticosteroid/po [Oral Drug Administration]
  • cyclophosphamide/cb [Drug Combination]
  • cyclophosphamide/ct [Clinical Trial]
  • cyclophosphamide/dt [Drug Therapy]
  • cyclophosphamide/iv [Intravenous Drug Administrati
  • disease classification
  • human
  • laboratory test
  • magnetic resonance angiography
  • mycophenolic acid 2 morpholinoethyl ester/ad [Drug
  • mycophenolic acid 2 morpholinoethyl ester/cb [Drug
  • mycophenolic acid 2 morpholinoethyl ester/dt [Drug
  • mycophenolic acid 2 morpholinoethyl ester/po [Oral
  • neuroimaging
  • nuclear magnetic resonance imaging
  • outcome assessment
  • pathogenesis
  • review
  • single photon emission computer tomography
  • treatment outcome

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Authors

  • Benseler S.M.

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