Central proinflammatory cytokines and pain enhancement

  • Wieseler-Frank J
  • Maier S
  • Watkins L
  • 67

    Readers

    Mendeley users who have this article in their library.
  • 135

    Citations

    Citations of this article.

Abstract

Enhanced pain is a component of the 'sickness response' which is an evolutionarily adaptive constellation of responses that enhance the survival of the host. Proinflammatory cytokines mediate these sickness behaviors, and whether proinflammatory cytokines are involved in exaggerated pain has become an intriguing question. Studies suggest that spinal cord glial cells (astrocytes and microglia) are activated in conditions that lead to enhanced pain. Not only is glial activation associated with enhanced pain, but it is also integral to the induction and maintenance of these pain states. Proinflammatory cytokines can be released by activated astrocytes and microglia within the central nervous system. This review will discuss the role of proinflammatory cytokines in experimental models of prolonged pain states. Administration of exogenous proinflammatory cytokines facilitates pain, and agents that antagonize proinflammatory cytokine actions have been shown to block and/or reverse enhanced pain. These findings suggest that blocking the synthesis and/or release of proinflammatory cytokines may be viable strategies for the treatment of pathological pain. Gene therapy to augment the endogenous anti-inflammatory cytokine, interleukin-10, is one of the more promising therapies currently under study.

Author-supplied keywords

  • Allodynia
  • Astrocyte
  • Hyperalgesia
  • Interleukin-1
  • Interleukin-6
  • Microglia
  • Pain facilitation
  • Proinflammatory cytokines
  • Sickness behavior
  • Tumor necrosis factor-alpha

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Julie Wieseler-Frank

  • Steven F. Maier

  • Linda R. Watkins

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free