Ceramide: A new second messenger of cannabinoid action

123Citations
Citations of this article
99Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Cannabinoids, the active components of Cannabis sativa (marijuana), and their endogenous counterparts exert their effects by binding to specific Gi/o-protein-coupled receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. Recent research has shown that the CB1 cannabinoid receptor is coupled to the generation of the lipid second messenger ceramide via two different pathways: sphingomyelin hydrolysis, and ceramide synthesis de novo. Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions.

Cite

CITATION STYLE

APA

Guzmán, M., Galve-Roperh, I., & Sánchez, C. (2001, January 1). Ceramide: A new second messenger of cannabinoid action. Trends in Pharmacological Sciences. Elsevier Ltd. https://doi.org/10.1016/S0165-6147(00)01586-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free