Cerebral amyloid angiopathy related inflammation: Three case reports and a review

  • Chung K
  • Anderson N
  • Hutchinson D
 et al. 
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Cerebral amyloid angiopathy related inflammation (CAA-I), previously described under various names, is a treatable encephalopathy usually occurring in older adults. Here, three patients are described with histopathologically confirmed CAA-I, and summarised data from the published literature are presented. CAA-I has a characteristic combination of clinical and radiological features. Definite diagnosis requires brain and leptomeningeal biopsy. A favourable response to immunosuppressive therapy is common and treatment without brain biopsy may be considered in selected patients. Diagnostic criteria for CAA-I are proposed.

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  • Kong Khi Chung

  • Neil E. Anderson

  • David Hutchinson

  • Beth Synek

  • P. Alan Barber

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