Cerebral edema associated with Gliadel wafers: Two case studies

  • Weber E
  • Goebel E
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Abstract

While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect. Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers. As a result, one of these individuals had premature death. A brief literature review is provided to assist in explaining the mechanisms by which clinically significant cerebral edema may develop.

Author-supplied keywords

  • Alkylating
  • Alkylating: administration
  • Alkylating: adverse effects
  • Antineoplastic Agents
  • Biocompatible Materials
  • Biocompatible Materials: adverse effects
  • Brain Edema
  • Brain Edema: etiology
  • Brain Edema: pathology
  • Brain Neoplasms
  • Brain Neoplasms: drug therapy
  • Carmustine
  • Carmustine: administration & dosage
  • Carmustine: adverse effects
  • Decanoic Acids
  • Decanoic Acids: adverse effects
  • Drug Implants
  • Female
  • Glioma
  • Glioma: drug therapy
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Polyesters
  • Polyesters: adverse effects

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Authors

  • Emil L. Weber

  • Eric A Goebel

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