Cerebral ischemia mediates the effect of serum uric acid on cognitive function

  • Vannorsdall T
  • Jinnah H
  • Gordon B
 et al. 
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Abstract

BACKGROUND AND PURPOSE: High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction. METHODS: One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan. RESULTS: Serum UA was associated (P

Author-supplied keywords

  • *Brain Ischemia/et [Etiology]
  • *Brain/pa [Pathology]
  • *Cognition Disorders/et [Etiology]
  • *Hyperuricemia/px [Psychology]
  • *Uric Acid/bl [Blood]
  • 268B43MJ25 (Uric Acid)
  • Adult
  • Aged
  • Brain Edema/et [Etiology]
  • Brain Edema/pa [Pathology]
  • Brain Ischemia/bl [Blood]
  • Brain Ischemia/pa [Pathology]
  • Cognition Disorders/bl [Blood]
  • Female
  • Humans
  • Hyperuricemia/co [Complications]
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders/bl [Blood]
  • Memory Disorders/et [Etiology]
  • Middle Aged
  • Myelin Sheath/pa [Pathology]
  • Verbal Learning

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Authors

  • T D Vannorsdall

  • H A Jinnah

  • B Gordon

  • M Kraut

  • D J Schretlen

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