The challenge of prion decontamination.

  • McDonnell G
  • Burke P
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Prions are a class of proposed proteinaceous infectious agents that cause similar fatal brain diseases. These diseases are known as transmissible sponiform encephalopathies (TSEs), and include Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler syndrome (GSS) in humans, bovine spongiform encephalopathy (BSE) in cattle (also variant CJD [vCJD] in humans), and scrapie in sheep. Iatrogenic transmission of these diseases via contaminated medical devices is considered rare, but it has been documented...

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  • Gerald McDonnell

  • Peter Burke

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