Characterization of genetic variation in TLR8 in relation to allergic rhinitis

  • Henmyr V
  • Lind-Halldén C
  • Carlberg D
 et al. 
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Background A previous investigation of all 10 TLR-genes for associations with allergic rhinitis (AR) detected a number of significant SNPs in the TLR8locus. The associations indicated that an accumulation of rare variants could explain the signal. The present study therefore searches for rare variants in the TLR8 region and also investigates the reproducibility of previous SNP associations. Methods The TLR8 gene was re-sequenced in 288 AR patients from Malmö and the data was compared with publically available data. Seven previously AR-associated SNPs from TLR8 were analyzed for AR-associations in 422 AR patients and 859 controls from the BAMSE cohort. The associations detected in present and previous studies were compared. Results Sequencing detected 13 polymorphisms (3 promotor, 10 coding) among 288 AR patients. Four of the coding polymorphisms were rare (MAF

Author-supplied keywords

  • TLR8
  • allergic rhinitis
  • association
  • rare variant
  • resequencing

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  • V. Henmyr

  • C. Lind-Halldén

  • D. Carlberg

  • C. Halldén

  • E. Melén

  • M. Wickman

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