Characterization of a murine gene expressed from the inactive X chromosome

  • Borsani G
  • Tonlorenzi R
  • Simmler M
 et al. 
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Abstract

In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation.

Author-supplied keywords

  • *Gene Expression
  • *X Chromosome
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Cosmids
  • Crosses, Genetic
  • DNA/genetics
  • Female
  • Humans
  • Male
  • Meiosis
  • Mice
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Polymerase Chain Reaction/methods
  • Recombination, Genetic
  • Sequence Homology, Nucleic Acid

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Authors

  • G Borsani

  • R Tonlorenzi

  • M Simmler

  • L Dandolo

  • D Arnaud

  • V Capra

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