Chemical nanoprinting: a novel method for fabricating DNA microchips.

  • Kumar A
  • Liang Z
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We have developed a novel cost-effective procedure, namely 'chemical nanoprinting', for oligonucleotide or cDNA chips manufacture. In this thermo-controlled process, the oligonucleotides, covalently attached to a highly loaded 'master-chip' through disulfide bonds, are chemically transferred to the acrylamide layer mounted on a 'print-chip'. It is demonstrated here that multiple identical print-chips can be produced from a single master-chip. This duplication process is a few hundreds of times faster than any existing methods and the speed of process and cost incurred are independent of the scale of the DNA chips.

Author-supplied keywords

  • DNA
  • DNA: analysis
  • DNA: chemical synthesis
  • Microchemistry
  • Microchemistry: instrumentation
  • Microchemistry: methods
  • Miniaturization
  • Oligonucleotide Array Sequence Analysis
  • Oligonucleotide Array Sequence Analysis: instrumen
  • Oligonucleotide Array Sequence Analysis: methods

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  • a Kumar

  • Z Liang

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