Chiral auxiliaries - Principles and recent applications

  • Gnas Y
  • Glorius F
  • 99


    Mendeley users who have this article in their library.
  • 125


    Citations of this article.


With modern methods for asymmetric catalysis breaking ground, the use of chiral auxiliaries seems to be old-fashioned and rather inefficient. However, for many transformations. chiral auxiliaries often represent the only selective method available. In addition, high levels of selectivity and reliability are often attractive characteristics of chiral auxiliaries and allow for the efficient and rapid synthesis of desired chiral compounds. In addition. even ill cases with imperfect selectivity, the use of ail attached chiral auxiliary allows the enrichment of diastereoselectivity, and hence enantioselectivity after removal of the auxiliary, by many standard separation techniques. This article gives ail overview oil the most important classes of chiral auxiliaries, discussing the mode of action and highlighting some recent applications. It does not deal with the use of chiral catalysts, chiral reagents or achiral auxiliaries.

Author-supplied keywords

  • Asymmetric synthesis
  • Chiral auxiliary
  • Diastereoselectivity
  • Oxazolidinones
  • SAMP
  • Sulfoxides

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Yvonne Gnas

  • Frank Glorius

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free