Chitosan chemistry: Relevance to the biomedical sciences

  • Muzzarelli R
  • Muzzarelli C
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A review. Chitin is well characterized in terms of anal. chem., is purified from accompanying compds., and derivatized in a variety of fashions. Its biochem. significance when applied to human tissues for a no. of purposes such as immunostimulation, drug delivery, wound healing, and blood coagulation is currently appreciated in the context of biocompatibility and biodegradability. Phys. forms (nanoparticles, nanofibrils, microspheres, composite gels, fibers, films) are as important as the chem. structures. Besides being safe to the human body, chitin and chitosan exert many favorable actions, and some chitin based products such as cosmetics, nutraceuticals, bandages, and textiles are presently com. available. This chapter puts emphasis on the development of new drug carriers and on the interaction of chitosans with living tissues, two major topics of the most recent research activities. [on SciFinder(R)]

Author-supplied keywords

  • Chemically modified chitosans
  • Chitosan
  • Microspheres
  • Nanoparticles
  • Nerve, cartilage and bone regeneration
  • Oral and nasal administration
  • Polyelectrolyte complexes
  • Wound dressing

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