Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study

  • Arsenault B
  • Lemieux I
  • Després J
 et al. 
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Abstract

AimsTo evaluate the association of low-density lipoprotein cholesterol (LDL-C) levels in small and large LDL particles with risk of incident coronary heart disease (CHD). Methods and resultsWe performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were apparently healthy men and women aged 4579 years who developed fatal or non-fatal CHD (n = 1035), and who were matched by age, gender, and enrollment time to 1920 controls who remained free of CHD. Electrophoretic characteristics of LDL particles were measured using 216% polyacrylamide gradient gel electrophoresis. Concentrations of LDL-C

Author-supplied keywords

  • Epidemiology
  • Gender
  • LDL particle size
  • Lipids
  • Risk factors

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Authors

  • Benoit J. Arsenault

  • Isabelle Lemieux

  • Jean Pierre Després

  • Nicholas J. Wareham

  • Robert Luben

  • John J.P. Kastelein

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