Choosing a method for phylogenetic prediction

  • Mount D
  • 154


    Mendeley users who have this article in their library.
  • 6


    Citations of this article.


INTRODUCTIONMaximum parsimony predicts the evolutionary tree or trees that minimize the number of steps required to generate the observed variation in the sequences from common ancestral sequences. For this reason, the method is also sometimes referred to as the minimum evolution method. A multiple sequence alignment (msa) is required to predict which sequence positions are likely to correspond. These positions will appear in vertical columns in the msa. For each aligned position, phylogenetic trees that require the smallest number of evolutionary changes to produce the observed sequence changes from ancestral sequences are identified. This analysis is continued for every position in the sequence alignment. Finally, those trees that produce the smallest number of changes overall for all sequence positions are identified. This method is best suited for sequences that are quite similar and is limited to small numbers of sequences.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • David W. Mount

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free