Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair

  • Thiriet C
  • Hayes J
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Abstract

A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair. Copyright ©2005 by Elsevier Inc.

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