Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes.

  • Kristinsson S
  • Björkholm M
  • Hultcrantz M
 et al. 
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Abstract

Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) often present with infections, but there are little data to assess whether a personal history of selected infections may act as pathogenic triggers. To additionally expand our knowledge on the role of immune stimulation in the causation of AML and MDS, we have conducted a large, population-based study to evaluate the risk of AML and MDS associated with a prior history of a broad range of infections or autoimmune diseases.

Author-supplied keywords

  • 80 and over
  • Acute
  • Acute: epidemiology
  • Acute: immunology
  • Adult
  • Aged
  • Autoimmune Diseases
  • Autoimmune Diseases: complications
  • Autoimmune Diseases: epidemiology
  • Autoimmune Diseases: immunology
  • Case-Control Studies
  • Communicable Diseases
  • Communicable Diseases: complications
  • Communicable Diseases: epidemiology
  • Communicable Diseases: immunology
  • Female
  • Humans
  • Leukemia
  • Logistic Models
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes
  • Myelodysplastic Syndromes: epidemiology
  • Myelodysplastic Syndromes: immunology
  • Myeloid
  • Odds Ratio
  • Registries
  • Risk Assessment
  • Risk Factors
  • Sweden
  • Sweden: epidemiology
  • Time Factors

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Authors

  • Sigurdur Y Kristinsson

  • Magnus Björkholm

  • Malin Hultcrantz

  • Åsa R Derolf

  • Ola Landgren

  • Lynn R Goldin

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