Chronic lymphocytic leukemia: new concepts and emerging therapies

  • Ahmadi T
  • Maniar T
  • Schuster S
 et al. 
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Abstract

OPINION STATEMENT: Remarkable progress in elucidating the biology of chronic lymphocytic leukemia (CLL) has been made over the last two decades. Improved understanding of CLL has lead to new prognostic tools and therapeutic options, and holds promise for eventually finding a cure for this disease. Challenges lie in incorporating the various treatment modalities, including chemotherapy, monoclonal antibodies, immunotherapeutic strategies and novel small molecules, into a comprehensive treatment strategy guided by the biological complexity of CLL.

Author-supplied keywords

  • Antibodies, Monoclonal/therapeutic use
  • Antigens, CD5/analysis
  • Antineoplastic Combined Chemotherapy Protocols/*th
  • B-Lymphocyte Subsets/pathology
  • Disease Progression
  • Drugs, Investigational/therapeutic use
  • Humans
  • Immunologic Factors/therapeutic use
  • Immunotherapy/*methods
  • Leukemia, Lymphocytic, Chronic, B-Cell/drug
  • Multicenter Studies as Topic
  • Neoplasm, Residual
  • Nitrogen Mustard Compounds/therapeutic use
  • Prognosis
  • Randomized Controlled Trials as Topic/statistics &
  • Salvage Therapy
  • therapy/genetics/surgery/*therapy

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Authors

  • T Ahmadi

  • T Maniar

  • S Schuster

  • E Stadtmauer

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